Amyloid imaging with positron emission tomography (PET), has produced remarkably consistent qualitative findings across a large number of centers; however, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. A common quantitative output value for beta-amyloid imaging applicable across tracers and methods will allow better comparison of data across sites, ultimately resulting in the application of universal diagnostic and prognostic values.
This has driven the creation of a 100-point scale termed “Centiloid,” which is an average value of zero in “high certainty” amyloid negative subjects and an average of 100 in “typical” Alzheimer’s disease (AD) patients (Klunk et al., 2015). Calibration to the Centiloid scale allows units that are more easily compared across sites. All data used in the Centiloid Project is available for download in the pages below.
Standard PiB (PET or DICOM) data:
[F-18] amyloid tracers:
CALIBRATION OF THE STANDARD PiB METHOD
These data can be used to scale global cortical PiB PET SUVr data to the Centiloid standard scale.
This is the basic dataset that most users will employ when doing Level 2 or Level 3 Centiloid scaling analyses. It consists of all of the AD-100 and YC-0 PiB PET 50-70 min data and the corresponding MR data in both DICOM and nifti formats.
This dataset is intended for users who are seeking to scale PiB PET data that is not 50-70 SUVr to the Centiloid scale. This would include dynamic PiB data (e.g., BPND) and SUVr data from a time period other than 50-70 min. This dataset may allow users to do this without acquiring any new PiB PET data. Users who seek to perform a standard Centiloid scaling analysis should use the 50-70 min dataset.
Disclaimer: This data is intended for users already experienced in the use of dynamic PET data. These users should refer to the “CentiloidPETFraming.xls” file as an aid to determining the framing of each subject dataset.
This is the data described in section 2.1.2 “The standard VOIs” in the Centiloid Project paper (Klunk et al. Alzheimers Dement 2015;11:1-15). This dataset was used to generate the average AD-CTX and average OC-CTX images - the difference between which at 1.05 SUVr units produced the standard cortical target (CTX) VOI.
Please email here for questions regarding the Centiloid Project.
W. E. Klunk et al., The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET. Alzheimers. Dement. 11, 1–4 (2015).